Review Highlights Knowledge of Alport Disease Cellular, Molecular, Mechanical Drivers

Changes in cellular and molecular signaling, as well as increased mechanical strain, likely contribute to the development and progression of kidney damage in Alport disease. An overview, “Collagen IV diseases: A focus on the glomerular basement membrane in Alport syndrome,” published in the journal Matrix Biology, explored what scientists…

Alport Syndrome-linked Hypertension Treated with Simple Procedure in Case Study

High blood pressure (hypertension), very common in patients with chronic kidney disease stage 5 and Alport syndrome, is known to raise these patients risk of death due to cardiovascular complications. Now researchers report that hypertension associated with Alport syndrome might be treated with kidney nerve denervation, a technique that destroys certain blood vessels…