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January 21, 2019January 21, 2019

Co-occurrence of aHUS, TMA, and Alport Syndrome Suggest Shared Mechanism, Case Report Says

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Abnormal activation of the immune system’s complement pathway — a common response to fight germs — may represent a mechanism shared among three distinct kidney conditions, a case report ... Read more

January 14, 2019January 14, 2019

In XLAS, COL4A5 Mutations Determine Progression of Hearing Loss, Study Finds

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Hearing loss in male patients with X-linked Alport syndrome (XLAS) is caused by sensorineural deafness that becomes worse with age. Also, the more serious the mutations carried by patients, ... Read more

January 7, 2019January 7, 2019

Genetic Testing More Reliable than Hematuria to Determine Alport’s Mode of Inheritance, Case Reports Show

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Genetic testing, not hematuria (blood in urine), is the more accurate method to diagnose Alport syndrome and determine its mode of inheritance within a family, a review of eight related cases reports. ... Read more

December 21, 2018December 21, 2018

Rising Healthcare Costs Strain EU Budgets Even as New Therapies Flourish

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Cash-strapped governments across the 28-member European Union are struggling to control runaway healthcare expenditures — at exactly the same time as the promise of new but expensive therapies to ... Read more

December 17, 2018December 17, 2018

Urinary Levels of CD80 Protein Not Suitable to Distinguish Between Types of Kidney Disease, Study Suggests

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Increased urinary excretion of the CD80 protein was found in all patients with active kidney diseases, including Alport syndrome, in a recent study, rendering the protein an unreliable diagnostic biomarker to ... Read more

December 10, 2018December 10, 2018

DNA Sequencing Technique Finds COL4A5 Mutations in 2 Alport Patients With No Relevant Family History

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A technique called whole-exome sequencing (WES) that screens the protein-coding region of the DNA enabled the identification of mutations in the COL4A5 gene in two girls with Alport syndrome ... Read more

December 3, 2018December 3, 2018

Newly Identified DDR1 I Inhibitor Can Prevent Kidney Fibrosis, Loss of Function in Alport Syndrome Mice

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Inhibition of the DDR1 enzyme with a newly identified small molecule compound can prevent renal tissue scarring and renal function loss in a mouse model of Alport syndrome, a ... Read more

November 26, 2018November 26, 2018

Patients in Japan Also Show Good Long-term Survival After Kidney Transplant and No Sign of Alport’s Return, Study Finds

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Alport syndrome (AS) patients in Japan undergoing a kidney transplant were found to have long-term survival rates similar to patients whose transplant was due to other causes of kidney failure, a ... Read more

November 19, 2018November 19, 2018

Careful Donor Evaluation Can Improve Alport Patients’ Kidney Transplant Outcomes

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Kidney transplantation in those with Alport syndrome may have better patient and graft survival rates compared to patients with other causes of end-stage renal disease (ESRD). Available evidence also ... Read more

November 12, 2018November 12, 2018

Sanofi Acquires Global Rights to RG-012, Investigational Alport Syndrome Therapy

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Under a restructured agreement with Regulus Therapeutics, Sanofi Genzyme now has sole responsibility for the development and marketing of the investigational therapy RG-012, currently under evaluation for the treatment of ... Read more