Australians Find Compound That Prevents the Protein Misfolding Seen in Alport Syndrome

Chemical compounds known as small chaperone molecules can prevent the protein-structure abnormalities associated with the most common type of Alport syndrome, Australian researchers report. This leads to normal production of the collagen protein that is missing in the disease. Gene mutations cause collagen to misfold. Naturally occurring chaperone molecules prevent misfolding,…