COL4A5 Protein Measurements in Alport Patients’ Kidneys May Aid in Prognosis, Researchers Say

The extent of loss of the COL4A5 protein in the kidneys of Alport syndrome patients is linked to a more severe disease progression, researchers at the Mayo Clinic in Minnesota argue. This feature, however, is not common in patients diagnosed with Alport in adulthood, according to the study,…

Correct Alport Diagnosis Crucial but Not Always Straightforward, Case Report Shows

A case report recently demonstrated that a correct diagnosis of Alport disease is crucial, but it may be difficult to distinguish from thin basement membrane disease — a similar kidney condition that doesn’t progress to kidney failure — and even biopsies can give inconclusive results. The study, “An Overlapping Case of Alport…