Posts by: Patricia Inacio, PhD

Patricia Inacio, PhD

Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.

June 24, 2019June 24, 2019

Ongoing Research Testing Several New Therapies for Alport Syndrome

News

While Alport syndrome currently remains without a cure, ongoing research is testing several strategies that hold promise, a review study shows. The review, “New therapeutic options for Alport syndrome,” ... Read more

May 13, 2019May 13, 2019

Patient Enrollment Completed for CARDINAL Study Testing Bardoxolone for Improving Kidney Function

News

Reata Pharmaceuticals has completed patient enrollment for Phase 3 of its CARDINAL study investigating the safety and efficacy of bardoxolone methyl (bardoxolone) for improving kidney function in people with ... Read more

April 22, 2019April 22, 2019

Young Patients with Alport Syndrome at Higher Risk for Kidney Infections with BK Virus after Transplant, Study Finds

News

Children and adolescents with Alport syndrome who underwent kidney transplants are at higher risk for developing kidney infections by BK virus, a South Korean study suggests. The study, “Higher ... Read more

January 28, 2019January 28, 2019

Potential Alport Biomarkers, Treatment Targets Identified in Stem Cell Analysis

News

Using stem cells derived from Alport syndrome (AS) patients to examine their genetic and protein profile, scientists identified three factors — microRNA-4775, ELV-like protein 1-A (ELAVL1), and epidermal growth factor ... Read more

December 17, 2018December 17, 2018

Urinary Levels of CD80 Protein Not Suitable to Distinguish Between Types of Kidney Disease, Study Suggests

News

Increased urinary excretion of the CD80 protein was found in all patients with active kidney diseases, including Alport syndrome, in a recent study, rendering the protein an unreliable diagnostic biomarker to ... Read more

August 20, 2018August 20, 2018

Patients’ Stem Cells a Potential New Cell Model for Alport Research, Study Suggests

News

Using induced pluripotent stem cells may help researchers identify the underlying mechanisms of Alport syndrome, according to a new study from Monash University in Austrialia. Researchers developed podocyte-like cells ... Read more

June 25, 2018June 25, 2018

Small Molecule Seen to Slow Alport’s Progression in Mouse Model of Disease

News

A small-inhibitor molecule targeting a protein called lysyl oxidase like-2 or LOXL2 was seen to lessen renal scarring and improve the workings of the kidney in a mouse model ... Read more

June 18, 2018June 18, 2018

EU Grants Bardoxolone Orphan Drug Status as Potential Alport Therapy, Phase 3 Trial Enrolling

News

The European Commission (EC) has granted orphan drug status to bardoxolone methyl (bardoxolone)as a possible treatment for Alport syndrome, the therapy’s developer, Reata Pharmaceuticals, announced. Its effectiveness and safety are ... Read more

May 21, 2018May 21, 2018

Recurrence of Kidney Inflammation a Risk Factor for Kidney Rejection After Transplant, Study Shows

News

In patients with acute kidney inflammation, also known as glomerulonephritis, recurrence of the disease is a significant factor underlying failed kidney transplants, a study suggests. The study, “Clinical Outcomes ... Read more

April 23, 2018April 23, 2018

Variations Between Alport, Pierson Syndromes Explain Kidney Damage Differences

News

While Alport syndrome and Pierson syndrome are two diseases caused by mutations in genes important for the correct functioning of the kidney’s filtration system, the two diseases have different manifestations. ... Read more

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