Posts by: Patricia Inacio, PhD

Patricia Inacio, PhD

Patricia holds her Ph.D. in Cell Biology from University Nova de Lisboa, and has served as an author on several research projects and fellowships, as well as major grant applications for European Agencies. She also served as a PhD student research assistant in the Laboratory of Doctor David A. Fidock, Department of Microbiology & Immunology, Columbia University, New York.

November 25, 2019November 25, 2019

Sangamo to Launch First-in-human Clinical Trial Testing TX200 Cell Therapy in End-stage Renal Disease

News

The United Kingdom’s Medicines Healthcare Products Regulatory Agency (MHRA) has authorized the first-in-human clinical trial testing Sangamo Therapeutics’ TX200, a cell-based CAR-Treg therapy, in preventing rejection of transplanted kidneys in patients ... Read more

September 9, 2019September 9, 2019

Pregnancy May Exacerbate Symptoms of Recessive Form of Alport Syndrome, Case Report Shows

News

Pregnancy may exacerbate the impact of COL4A4 gene mutations in women who have recessive, or non-symptomatic forms of Alport syndrome, a case report shows. Published in the journal Nephron, the ... Read more

July 22, 2019July 22, 2019

Rare Genetic Mutation Leads to Severe X-linked Alport Syndrome in 10-year-old Boy, Case Study Finds

News

A rare type of mutation in the COL4A5 gene in a young boy led to severe X-linked Alport syndrome, according to a case report. The report, “Somatic Mosaicism in a Male ... Read more

June 24, 2019June 24, 2019

Ongoing Research Testing Several New Therapies for Alport Syndrome

News

While Alport syndrome currently remains without a cure, ongoing research is testing several strategies that hold promise, a review study shows. The review, “New therapeutic options for Alport syndrome,” was ... Read more

May 13, 2019May 13, 2019

Patient Enrollment Completed for CARDINAL Study Testing Bardoxolone for Improving Kidney Function

News

Reata Pharmaceuticals has completed patient enrollment for Phase 3 of its CARDINAL study investigating the safety and efficacy of bardoxolone methyl (bardoxolone) for improving kidney function in people with Alport ... Read more

April 22, 2019April 22, 2019

Young Patients with Alport Syndrome at Higher Risk for Kidney Infections with BK Virus after Transplant, Study Finds

News

Children and adolescents with Alport syndrome who underwent kidney transplants are at higher risk for developing kidney infections by BK virus, a South Korean study suggests. The study, “Higher Incidence ... Read more

January 28, 2019January 28, 2019

Potential Alport Biomarkers, Treatment Targets Identified in Stem Cell Analysis

News

Using stem cells derived from Alport syndrome (AS) patients to examine their genetic and protein profile, scientists identified three factors — microRNA-4775, ELV-like protein 1-A (ELAVL1), and epidermal growth factor receptor ... Read more

December 17, 2018December 17, 2018

Urinary Levels of CD80 Protein Not Suitable to Distinguish Between Types of Kidney Disease, Study Suggests

News

Increased urinary excretion of the CD80 protein was found in all patients with active kidney diseases, including Alport syndrome, in a recent study, rendering the protein an unreliable diagnostic biomarker to differentiate ... Read more

August 20, 2018August 20, 2018

Patients’ Stem Cells a Potential New Cell Model for Alport Research, Study Suggests

News

Using induced pluripotent stem cells may help researchers identify the underlying mechanisms of Alport syndrome, according to a new study from Monash University in Austrialia. Researchers developed podocyte-like cells — ... Read more

June 25, 2018June 25, 2018

Small Molecule Seen to Slow Alport’s Progression in Mouse Model of Disease

News

A small-inhibitor molecule targeting a protein called lysyl oxidase like-2 or LOXL2 was seen to lessen renal scarring and improve the workings of the kidney in a mouse model of ... Read more