Author Archives: Joana Carvalho

Sulfatides May Play Important Role in Early Stages of Alport Syndrome, Mouse Study Says

Scientists found two molecules called sulfatides in the kidneys of a mouse model of Alport syndrome that may play an important role during the early stages of the disease. The findings of the study, “Two Specific Sulfatide Species Are Dysregulated during Renal Development in a Mouse Model…

Gene Therapy Aiming to Restore COL4 Protein Not Likely to Succeed, Study in Mice Reports

Targeted gene therapy on cells that line the blood vessels — called endothelial cells — failed to restore production of normal collagen in a mouse model of Alport syndrome, a study reports. The study, “Endothelial Cell-Specific Collagen IV α3 Expression Does not Rescue Alport Syndrome in Col4a3-/-…